InBio is delighted to announce that it has recently expanded its unique and exclusive product line of human IgE monoclonal antibodies (hIgE mAb). Notably, this latest tranche of hIgE mAb includes many immunodominant allergens for dust mite, cat, dog, peanut and shellfish. In several cases, the IgE epitope structure has been determined and pairs of hIgE mAb can be used for cross-linking in basophil and mast cell activation tests.

InBio’s hIgE mAb product line serves the allergy and immunology community as unambiguous reference standards for research and diagnostic purposes, providing a promising alternative to human sera.

The current panel comprises 55 hIgE mAb to major food and inhaled allergens from dust mite, cat, dog, peanut, cashew, walnut, egg, and alpha-gal. The hIgE mAb are derived from allergic patients with a clinical history of allergic disease using proprietary methods. Multiple antibodies are available for specific target allergens, providing options for research applications and mechanistic studies of allergen-IgE interactions.

Applications for the hIgE mAb include:

• QC and validation of purified allergens for molecular diagnostics
• In vitro IgE diagnostic tests, calibrators, controls, alternatives to human sera
• Molecular reference standards for IgE
• Epitope analysis and localization of IgE epitopes
• Mast cell/basophil activation assays and histamine release
• Animal models of anaphylaxis