Greetings,

InBio is excited to ‘start’ the year at the American Academy of Allergy Asthma and Immunology annual meeting in San Diego next week. We enjoy the camaraderie among fellow scientists and the opportunity to engage in meaningful discussions about advances in the allergy/immunology field.

InBio scientists and collaborators will have nine poster presentations spread throughout the meeting. For the first time, we present the molecular structures of human IgE epitopes on the major cat and dog allergens, Fel d 1 and Can f 1, together with IgE epitope repertoire of mite Der p 2 and the generation of hypoallergens.

Several posters feature recent work on peanut and egg allergens. Composites are coming! This new approach to allergy diagnostics uses a formulation of purified peanut allergens instead of allergen extract for in vitro diagnostics. We also investigated the effect of extracting peanut allergens in distilled water and Kool Aid, a commonly used oral immunotherapy (OIT) protocol among allergists in the U.S. (spoiler alert: it’s not good).

You can find a list of InBio posters here. We welcome the opportunity to meet with you at the poster sessions and at the InBio exhibit #1747.

Finally, InBio would like to express its strong support for our fellow government scientists at the NIH, the FDA, the CDC and the USDA in these challenging times.

With gratitude,
Martin Chapman, PhD
President and CEO

InBio will be at Booth 1747. Stop by to discuss the latest developments in allergens, molecular diagnostics, food allergy and indoor air quality.

Please find details of InBio’s presentations at the AAAAI meeting below.

Friday, February 28^th, 2025

Poster #115: IgE Reactivities of Ara h 1 Vicilin Buried Peptide and Purified Natural Ara h 1; Revisiting the Conformational Epitopes
Presenter: Sayeh Agah, PhD
Session: Diagnosis and Natural History
Date/Time: Friday, February 28th at 2:45-3:45 PM

Poster #135: Improved In-vitro Allergy Diagnostics Using a Molecular Composite of Purified Peanut Allergens
Presenter: Sabina Wuenschmann, PhD
Session: Diagnosis and Natural History
Date/Time: Friday, February 28th at 2:45-3:45 PM

Saturday, March 1^st, 2025

Poster #445: Deficiencies of Allergen Levels in a Commonly Used Protocol for Peanut Oral Immunotherapy: Proceed with Caution.
Presenter: Stephanie Filep
Session: Immunotherapy, Biologics, and Novel Therapeutics
Date/Time: Saturday March 1^st, at 9:45-10:45 AM

Poster #519: Hypoallergenic Der p 2 Mutants Based on the Structure of Allergen-human IgE mAb Complexes
Presenter: Anna Pomés, PhD
Session: Novel Mechanisms of Mast Cells, Basophils and IgE
Date/Time: Saturday March 1^st, at 9:45-10:45 AM

Poster #115: Comparison of the Variability of Peanut-Containing Products Used in Oral Immunotherapy for Peanut Allergy
Session: Immunotherapy, Biologics, and Novel Therapeutics
Date/Time: Saturday March 1^st, at 9:45-10:45 AM

Poster #386: In Vivo Functional Activity of Structurally Defined Human IgE Monoclonal Antibody Epitope on Natural and Recombinant Cat Allergen Fel d 1
Session: Environment and Climate Change: Mechanisms and Outcomes
Date/Time: Saturday March 1st, 9:45 am – 10:45 am

Poster #495: Quantification of Major Allergens in Bee Pollen Supplements Compared to Pharmaceutical Allergy Immunotherapy Tablets
Session: Allergic Rhinitis, Nonallergic Rhinitis (NAR), Ocular Allergy and Immunotherapy
Date/Time: Saturday March 1st, 9:45 am – 10:45 am

Poster #538: Human IgE mAbs Structurally Define Two Partially Overlapping Epitopes on the Major Dog Allergen Can f 1
Session: Novel Mechanisms of Mast Cells, Basophils and IgE
Date/Time: Saturday March 1^st, at 9:45-10:45 AM

Sunday, March 2^nd, 2025

Poster #782: Creation of a Standardized Egg Ladder for use in IgE-mediated Egg Allergy
Session: Clinical Management
Date/Time: Sunday March 2nd, at 9:45-10:45 AM