Scientific Publications Using Our Products

Selected recent scientific publications using INDOOR Biotechnologies purified allergens.

Mouse models of asthma

Kelada SN, Wilson MS, Tavarez U, Kubalanza K, Borate B, Whitehead GS, Maruoka S, Roy MG, Olive M, Carpenter DE, Brass DM, Wynn TA, Cook DN, Evans CM, Schwartz DA, Collins FS. Strain-dependent genomic factors affect allergen-induced airway hyperresponsiveness in mice. Am J Respir Cell Mol Biol. 2011 Oct;45(4):817-24.

Trompette, S. Divanovic, A. Visintin, C. Blanchard, R. S. Hegde, R. Madan, P. S. Thorne, M. Wills-Karp, T. L. Gioannini, J. P. Weiss & C. L. Karp. Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature 2009; 457: 585-588

Schmitz N, Dietmeier K, Bauer M, Maudrich M, Utzinger S, Muntwiler S, Saudan P, Bachmann MF. Displaying Fel d1 on virus-like particles prevents reactogenicity despite greatly enhanced immunogenicity: a novel therapy for cat allergy. J Exp Med. 2009;206(9):1941-55.

T-Cell Studies:

Reefer AJ, Hulse KE, Lannigan JA, Solga MD, Wright PW, Kelly LA, Patrie J, Chapman MD, Woodfolk JA. Flow cytometry imaging identifies rare TH2 cells expressing thymic stromal lymphopoietin receptor in a "proallergic" milieu. J Allergy Clin Immunol. 2010 Nov; 126(5):1049-58, 1058.e1-10.

Hulse KE, Reefer AJ, Engelhard VH, Patrie JT, Ziegler SF, Chapman MD, Woodfolk JA. Targeting allergen to FcγRI reveals a novel TH2 regulatory pathway linked to thymic stromal lymphopoietin receptor. J Allergy Clin Immunol. 2010 Jan; 125(1):247-56.e1-8.

P. Royer, M. Emara, C. Yang, A. Al-Ghouleh, P. Tighe, N. Jones, H. F. Sewell, F. Shakib, L. Martinez-Pomares, and A. M. Ghaemmaghami. The Mannose Receptor Mediates the Uptake of Diverse Native Allergens by Dendritic Cells and Determines Allergen-Induced T Cell Polarization through Modulation of IDO Activity. Journal of Immunology 2010; 185: 1522-1531

Allergen Structure, X-Ray Crystallography

Chruszcz M, Chapman MD, Osinski T, Solberg R, Demas M, Porebski PJ, Majorek KA, Pomés A, Minor M. Alternaria alternata allergen, Alt a 1 - a unique, β-barrel protein dimer exclusively found in fungi. J Allergy Clin Immunol. 2012. In press.

Mueller GA, Gosavi RA, Krahn JM, Edwards LL, Cuneo MJ, Glesner J, Pomés A, Chapman MD, London RE, Pedersen LC. The Der p 5 crystal structure provides insight into the Group 5 dust mite allergens. J Biol Chem. 2010 Jun 9.

Mueller GA, Edwards LL, Aloor JJ, Fessler MB, Glesner J, Pomés A, Chapman MD, London RE, Pedersen LC. The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins. J Allergy Clin Immunol. 2010 Apr;125(4):909-917.

Chruszcz M, Chapman MD, Vailes LD, Stura EA, Saint-Remy JM, Minor W, Pomés A. Crystal structures of mite allergens Der f 1 and Der p 1 reveal differences in surface- exposed residues that may influence antibody binding. J Mol Biol. 2009 Feb 20;386(2):520-30.

Allergen antibody interactions

Chruszcz M, Pomés A, Glesner J, Vailes LD, Osinski T, Porebski PJ, Majorek KA,Heymann PW, Platts-Mills TA, Minor W, Chapman MD. Molecular determinants for antibody binding on group 1 house dust mite allergens. J Biol Chem. 2012 Mar 2;287(10):7388-98.

Glesner J, Wünschmann S, Li M, Gustchina A, Wlodawer A, Himly M, Chapman MD, Pomés A. Mechanisms of allergen-antibody interaction of cockroach allergen Bla g 2 with monoclonal antibodies that inhibit IgE antibody binding. PLoS One. 2011;6(7):e22223.

Li M, Gustchina A, Glesner J, Wünschmann S, Vailes LD, Chapman MD, Pomés A, Wlodawer A. Carbohydrates contribute to the interactions between cockroach allergen Bla g 2 and a monoclonal antibody. J Immunol. 2011 Jan 1;186(1):333-40.

Li M, Gustchina A, Alexandratos J, Wlodawer A, Wünschmann S, Kepley CL, Chapman MD, Pomés A. Crystal structure of a dimerized cockroach allergen Bla g 2 complexed with a monoclonal antibody. J Biol Chem. 2008;283:22806-14.

Allergen Standardization

Filep S, Tsay A, Vailes L, Gadermaier G, Ferreira F, Matsui E, King EM,Chapman MD. A multi-allergen standard for the calibration of immunoassays: CREATE principles applied to eight purified allergens. Allergy. 2012;67(2):235-41.

Filep S, Tsay A, Vailes LD, Gadermaier G, Ferreira F, Matsui E, King EM,Chapman MD. Specific allergen concentration of WHO and FDA reference preparations measured using a multiple allergen standard. J Allergy Clin Immunol. 2012;129(5):1408-10.

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