Purified Allergens

FOCUS ON.... articles are short articles providing compact scientific information about allergens.

FOCUS ON….Shrimp Tropomyosin, the major allergen in shellfish.

FOCUS ON.... Ara h 1, one of the most important peanut allergens.

FOCUS ON.... Fel d 1, the major cat allergen.

FOCUS ON....Mite Allergenicity. In this article, we focus on the resurgence of data on the structural diversity of mite allergens.

FOCUS ON... Alt a 1, the major allergen of Alternaria alternata.


Allergen Nomenclature.

Allergens and Allergen Immunotherapy: Subcutaneous, sublingual and oral. 5th EditionClick here to see a book chapter providing a historic overview and a review of the current use of the allergen nomenclature .

Allergens and Allergen Immunotherapy: Subcutaneous, sublingual and oral. 5th Edition. Edited by Richard F. Lockey and Dennis K. Ledford.  CRC Press, Taylor and Francis Group, Boca Raton, Florida, USA, 2014, pp 37-49.

The following table from the book chapter lists online databases for Allergen Nomenclature and protein structure.

Database Locator
WHO/IUIS Allergen Nomenclature Sub-Committee www.allergen.org*
Structural Database of Allergenic Proteins (SDAP) http://fermi.utmb.edu/SDAP
Food Allergy Research and Resource Program (Farrp) www.allergenonline.com
Protall www.ifr.bbsrc.ac.uk/protall
Allergome www.allergome.org
* Official website of the WHO/IUIS Sub-committee on allergen nomenclature.

Allergen Standardization

In 2001, the CREATE project, funded by the European Union, was started to support introduction of major allergen based standardization. The aim was to produce international standards of purified allergens with verifiable allergen content. The following papers give an overview of the achievements of the CREATE project.

Van Ree et al, Allergy 2008; 63:310-326        Chapman et al, J Allergy and Clin Immunology 2008;122:882-9


EDQM Allergen Reference Standards

As a result of the CREATE project, two recombinant allergens, rBet v 1 and rPhl p 5a, have been established within the Biological Standardization Programme (BSP-90) and were adopted by the European Pharmacopoeia Commission as Recombinant Major Allergen rBet v 1 CRS (Chemical Reference Substance) and Recombinant Major Allergen rPhl p 5a CRS, respectively. These reference preparations are intended for determination of the Bet v 1 and Phl p 5a content of allergen extracts or purified allergens by ELISA: available from the EDQM under catalogue numbers Y0001565 (rBet v 1) and Y0001566 (rPhl p 5a. 

EDQM reference standards page                    How to order EDQM reference standards


iFAAM - Integrated Approaches to Food Allergen and Allergy Risk Management

The World's Biggest Ever Study of Allergies

Indoor Biotechnologies Ltd is participating in the world's biggest study of food allergies. The €9m European Union funded project, "Integrated Approaches to Food Allergen and Allergy Risk Management (iFAAM)" is co-ordinated by Professor Clare Mills and colleagues at the University of Manchester and aims to produce a standardized management process for companies involved in food manufacturing. It will also develop tools designed to enforce these regulations and produce knowledge to inform new health advice on nutrition.

Indoor Biotechnologies is one of six UK participants in the 38-partner study which also involves leading experts from Europe, Australia and the US. Indoor Biotechnologies' role on the project will be the development of a multiplex immunoassay for the detection of food allergens. The multiplex food allergen array will enable a large panel of food allergens to be measured simultaneously and will have multiple applications in the food industry.

 

 

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