i) Monoclonal antibodies

InBio has unique capabilities and technology for environmental allergen detection. The core of InBio’s intellectual property (IP) is a comprehensive and proprietary portfolio of monoclonal antibodies to house dust mite allergens, animal allergens, cockroach, mold, pollen and food allergens. The company has an exclusive, perpetual, worldwide license for antibodies to indoor allergens from the University of Virginia Patent Foundation and in 2008 obtained an exclusive license for antibodies from Sanquin Research, Amsterdam, The Netherlands.

InBio owns proprietary antibody cell lines for dog, cockroach, peanut and mold allergens. These antibodies are used in InBio’s immunoassay platforms (ELISA and MARIA®) and in our Ventia™ ‘point-of-care’ device for dust mite allergen testing. InBio continues to produce (or acquire) allergen specific antibodies to add to its product portfolio and to consolidate its position as the leading supplier of allergen detection systems.

ii) InBio Agreement With Luminex Corp. for xMAP® Technology

In 2007, InBio signed a Development and Supply Agreement with Luminex Corporation (AUSTIN, Texas) which provides InBio with worldwide rights for use of Luminex xMAP®-based technology in the allergy field. InBio will market its Multiplex ARray for Indoor Allergens (MARIA®) kits for detection of dust mite, cat, dog, rat, mouse, cockroach allergens in homes, workplaces and public buildings, and will provide exclusive multiplex assay services to academic researchers, government agencies, pharmaceutical companies and the indoor air quality industry. InBio will also use Luminex’s xMAP® technology to develop tests for diagnosis of allergic disease using highly purified allergens.

iii) DUSTREAM® Collector Patent

InBio was granted a U.S. patent for the DUSTREAM® collector in November 2009 (U.S. Patent No. 7,617,566). The collector is only available through InBio and other authorized distributors and partners.

InBio has a worldwide exclusive license agreement with Allergopharma Joachim Ganzer (Hamburg, Germany) for production of recombinant allergen proteins and cDNA for research use. InBio also has worldwide, exclusive rights to market cockroach allergen sequences, covered by US Patent 5,869,288, from the University of Virginia Patent Foundation. BIOMAY AG (Vienna, Austria) has patents on Bet v 1, Bet v 2, Phl p 2 and Art v 1 sequences. InBio has certain rights to supply allergens produced by BIOMAY in the U.S. and Canada. InBio also has a license with Research Corporation Technologies (Tucson, AZ) for production of recombinant allergens in Pichia pastoris expression systems.

Registered Trademarks: INDOOR®, DUSTREAM®, MARIA® and our “Y-logo” are registered trademarks in the USA, Japan, and the European Union. LoTox™ and Ventia™ are also trademarks of InBio.