Recent studies by Cook and colleagues at NIEHS suggest that exposure to bacterial flagellin, which binds to toll-like receptor 5, can prime allergic responses to indoor allergens (see reference).
As part of a new initiative in innate immunity, Indoor Biotechnologies offers bacterial flagellin as a new product line. Indoor Biotechnologies has an SBIR Phase I grant to develop a high throughput immunoassay to measure environmental exposure to flagellin. As part of these studies, we have a new product - purified flagellin (~90% purity) from Bacillus subtilis.
|Storage:||Store at -20ºC|
|Notes:||Purifty verified by mass spectrometry and monoclonal antibody binding|
|Product Resources:||Please inquire|
|For Research Use Only: Not for Diagnostic or Therapeutic Use|
Wilson RH, Maruoka S, Whitehead GS, Foley JF, Flake GP, Sever ML, Zeldin DC, Kraft M, Garantziotis S, Nakano H, Cook DN. The Toll-like receptor 5 ligand flagellin promotes asthma by priming allergic responses to indoor allergens. Nat Med. 2012 Nov;18(11):1705-10. doi: 10.1038/nm.2920. Epub 2012 Oct 14. PubMed PMID: 23064463; PubMed Central PMCID: PMC3493750.